Creosote compound.



'RUDOLPHNBEIRENDES, or ELBERFELD, GERMANY, ASSIGNOR To 'FARBEN- PATENT OFFICE.

FABRIKEN VORM. FRIEDR. BAYER & 00., OF-ELBERFELD, GERMANY,

A co PoRA'rroNpF GER-MANY.

(m sosoflz COMPOUND.

Specification of Letters Patent.

Patented July 3, 1906.

Applieationfiled March 81,1906. serinnmsoads'z.

To all whomfitmay concern:

. Be it known that'I, RUDOLPH'BERENDES, doctor of hilosophy, chemist, a citizen ofthe German mpire, residing at Elberfeld, Kingdom of Prussia, Germany, have invented new and useful Improvements in New Creosote Compounds, of which the following is a specificatlon.

In another application for Letters Patent, being Serial No, 309 ,096, also filed March 31, 1906, I have described the production of new pharmaceutical products which are chemically alkyloxy-acetyl com oundsof' yroto my researches t catechinmonoalkylethers. that creosote can also be converted into alkyloxy-acetyl compounds and that according e resulting products likewise possess valuable therapeutic roperties, especially for the treatment of tu erculosis, andthe absence of any odor, their freedom from irritation, non-toxicity, and ability of being easilyreabsorbed render their outward apphcation highly satisfactory, an average dose being between from one to three grams for one external'application. I

The process for producing the new comounds consists in treating creosote with al-.

yloxyacetic acid or der1vativesther'eofsuch as ethoxy or methoxy acetic acid, eth: oxyacetyl chlorid, or the likein such manner as to roduce esterification. -The new products t us roduced are colorless liquids, soluble in alco 01 and ether. When reacted upon-by dilute caustic alkalies, they are split up into creosote and alkyloXy-acetic acid. Creosote being, as is known, a mixture of difi'erent phenols, mainly guaiacol, creosol, and cresol, by the term alkyloxy-acetyl compounds of creosote I. mean a mixture of the alkyloXy-acetyl compounds of the phenols of which creosote consists.

In carrying out my process practically I can roceed as follows, the partsbemg by weig t: One hundred and thirty-eight parts of creosote and forty parts of caustic soda are dissolved in one thousand parts of water and to the resulting solution one hundred and twenty m' limeters. have now ound twenty-two and one-half parts of ethoxyacetyl chlorid are added. After thevchlorid has entered Into reaction the mixture is shaken with ether, which will extract the new ester. The ethereal solution is then separated from the water, shaken withhighly-dilute caustic soda. to remove unchanged creosote,.and dried. The ether is driven off and- ,the residue is distilled oacuo.

-The ethoxy-acetyl compound of creosote is a limpid oil which boils at from 152 to 176- centi rade undera pressure of about It is easily soluble in alcohol and ether and is split up into ethoxyaceticacid and creosotewhen reacted upon by dilutecaustic alkalies.-

Having now described my invention and in what manner the same is to be performed,

whatI claim as new, and desire to secure by Letters Patent, is-

1. The herein-described new alkyloxyacet'yl compounds ofcreosote, obtainable by the action of alkyloxy-acetyl chlorid on creorsote, being colorless liquids soluble in ether and alcohol; liberatin creosote when reacted upon by dilute caust c alkalies and exhibitm valuable therapeutic properties, substantia ly ashereinbefore described.

2. The herein-described new ethoXy-acetyl compound of creosote, obtainable by the action of ethoxy acetyl'chlorid oncreosote be- "ing a limpid colorless oil boiling at from 152 to 176 Centigrade under a pressure of about twenty millimeters; being solublein alcohol RUDOLPH BERENDES. I

Witnesses Or'ro Konre, ARTHOR MATTHKUS. 

